Semaglutide + Hormone Therapy: Why They May Work Better Together in MidlifeBlog Post
It’s not just you.
You’re eating better, moving more, maybe even trying a medication like semaglutide (Ozempic, Wegovy)… but progress still feels slower than it should be. If you’re in perimenopause or menopause, your hormones might be part of that story.
A new Mayo Clinic study looked at postmenopausal women using semaglutide and found something fascinating:
💥 Women who were also on hormone therapy lost more weight at every check-in point — 3, 6, 9, and 12 months — than those who weren’t on hormones.
What the study found
Researchers followed over a hundred women who were taking semaglutide.
Some were also on menopause hormone therapy (HT) — estrogen, progesterone, or a combination — and had been for a while.
Here’s what happened:
Women using both semaglutide and hormone therapy lost more total weight at every time point.
More of them reached that “magic 10% weight loss” mark.
And both groups — with or without HT — saw better numbers for blood sugar, cholesterol, and blood pressure.
So while semaglutide helped everyone, hormone therapy seemed to give an extra boost.
Why hormones matter
When estrogen declines, your body composition changes — more fat storage (especially around the belly), less muscle, and a slower metabolism.
Hormone therapy can help stabilize those shifts, making it easier for medications like semaglutide to do their job.
It’s not about replacing willpower — it’s about working with your biology, not against it.
What this means for you
This doesn’t mean everyone should jump on hormone therapy. The study was small and observational — meaning it shows a pattern, not proof.
But it does remind us of something powerful:
When hormones are balanced, your metabolism responds better.
My takeaway for midlife women
If you’re struggling to lose weight despite your best efforts, you’re not failing — your physiology is shifting.
When we use the right tools — hormone therapy, nutrition, movement, mindset, and medication — we can reset your metabolism and help your body work with you again.
